By Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS
Pharmaceutics is among the such a lot varied topic parts in all of pharmaceutical technological know-how. in short, it truly is involved in the clinical and technological elements of the layout and manufacture of dosage varieties or medicinal drugs. An figuring out of pharmaceutics is hence important for all pharmacists and people pharmaceutical scientists who're concerned with changing a drug or a possible drug right into a medication that may be brought thoroughly, successfully and with ease to the patient.
Now in its fourth variation, this best-selling textbook in pharmaceutics has been introduced thoroughly brand new to mirror the fast advances in supply methodologies through eye and injection, advances in drug formulations and supply tools for distinctive teams (such as youngsters and the elderly), nanomedicine, and pharmacognosy. even as the editors have striven to take care of the accessibility of the textual content for college kids of pharmacy, holding the stability among being a certainly pitched introductory textual content and a transparent mirrored image of the country of the art.
provides a logical, accomplished account of drug layout and manufacture
includes the technological know-how of formula and drug delivery
designed and written for newbies to the layout of dosage forms
New to this edition
New editor: Kevin Taylor, Professor of medical Pharmaceutics, college of Pharmacy, college of London.
Twenty-two new contributors.
Six new chapters protecting parenteral and ocular supply; layout and management of medications for the kids and aged; the newest in plant medications; nanotechnology and nanomedicines, and the supply of biopharmaceuticals.
Thoroughly revised and up-to-date all through.
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Extra resources for Aulton's Pharmaceutics: The Design and Manufacture of Medicines
This is a particular problem with early preformulation samples which are often impure, and here special care must be taken (discussed further in Chapter 23). • A saturated solution must be obtained before any solution is removed for analysis and then all undissolved material removed prior to analysis. • The method of separating a sample of saturated solution from undissolved solute must be satisfactory. • The method of analysing the solution must be suf ciently accurate and reliable. • Temperature must be adequately controlled.
G. fumed silica). Studies of the compactability of drug substances are frequently undertaken using instrumented tablet machines in formulation laboratories to examine the tableting potential of the material in order to foresee any potential problems during compaction, such as lamination or sticking, which may require modi cation of the formulation or processing conditions. The rape utic c o ns ide ratio ns in do s ag e fo rm de s ig n The nature of the clinical indication, disease or illness for which the drug is intended is an important 17 C H AP TE R 1 factor when selecting the range of dosage forms to be prepared.
For drugs administered in liquid form, the stability in solution as well as the effects of pH over the physiological range of 1–8 should be understood. Buffers may be required to control the pH of the preparation to improve stability; where liquid dosage forms are sensitive to microbial attack, preservatives are required. In these formulations, and indeed in all dosage forms incorporating additives, it is also important to ensure that the components, which may include additional drug substances as in multivitamin preparations, do not produce chemical interactions themselves.