Get Apoptosis, Cell Signaling, and Human Diseases: Molecular PDF

By Rakesh Srivastava

(for either volumes) Apoptosis, mobile Signaling, and Human ailments: Molecular Mechanisms, Volumes 1 & 2, current a concise synthesis of contemporary advancements within the figuring out of either cellphone survival and apoptotic pathways. specific awareness is given to apoptosis in human ailments, comparable to diversified types of melanoma and neurodegenerative ailments. those finished volumes combine the main cutting edge and present findings from a number of similar disciplines of medical examine, together with pathology, genetics, virology, phone biology, immunology, and molecular biology. quantity 1 is split into sections: "Malignant Transformation and Metastasis" and "Molecular foundation of sickness Therapy." quantity 2 follows the same constitution and is split into sections entitled "Kinases and Phosphate" and "Molecular foundation of mobile Death." the entire participants are on the vanguard of medical discovery, and the studies they current systemically learn the main interesting and cutting edge elements in their specific parts of craftsmanship. Researchers will locate those volumes of significant gain as they look for novel and better remedies for human illnesses.

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A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining. J Biol Chem 2004;279:55,196–55,201. 95. Parrilla-Castellar ER, Arlander SJ, Karnitz L. Dial 9-1-1 for DNA damage: the Rad9-Hus1Rad1 (9-1-1) clamp complex. DNA Repair (Amst) 2004;3:1009–1014. 96. Durgerian S, Taylor SS. The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase. J Biol Chem 1989;264: 9807–9813.

Tortora G, Bianco R, Damiano V, et al. Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production. Clin Cancer Res 2000;6:2506–2512. 147. Wang H, Hang J, Shi Z, et al. Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.

149. Tortora G, Ciardiello F. Targeting of epidermal growth factor receptor and protein kinase A: molecular basis and therapeutic applications. Ann Oncol 2000;11:777–783. 150. Yang WL, Iacono L, Tang WM, Chin KV. Novel function of the regulatory subunit of protein kinase A: regulation of cytochrome c oxidase activity and cytochrome c release. Biochemistry 1998;37:14,175–14,180 151. Srivastava RK, Srivastava AR, Park YG, Agrawal S, Cho-Chung YS. Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.

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