By Harry G. Brittain
Even if the legitimate compendia outline a drug substance as to identification, purity, power, and caliber, they as a rule don't supply different actual or chemical information, nor do they checklist equipment of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered through the medical literature and the records of pharmaceutical laboratories. Edited via the affiliate Director of Analytical learn and improvement for the yank organization of Pharmaceutical Scientists, Analytical Profiles of Drug ingredients and Excipients brings this knowledge jointly into one resource. The scope of the sequence has lately been increased to incorporate profiles of excipient fabrics.
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Extra info for Analytical Profiles of Drug Substances, Excipients, and Related Methodology
8 m x 2 mm glass column with 3 % OV-l ion 100-120 mesh Veraport 30 is used to effect the analytical separation. , injection port at 2OO0C, and the FID detector at 280°C. Nitrogen is used as the carrier gas at a flow rate of 20 mL/min. 5% SE-30 on 100 mesh Chromosorb G 80 . An oven temperature of about 1 18°C and a nitrogen carrier flow rate of 45 mlimin. were used. ) at 5"C/min. for the separation of 20 substances (including benzoic acid) in cologne . A HP-5871 mass selective detector was used.
For the separation of 20 substances (including benzoic acid) in cologne . A HP-5871 mass selective detector was used. Supelco Inc. 32 mm; 1 pm film) for the analysis of 25 semi-volatile acids, including benzoic acid [3 I]). , helium carrier gas at 35 mWmin, and a MS detector. 34 G U N A W A N INDRAYANTO ETAL. 3 GUNAWAN INDRAYANTO ETAL. 6 mm column and a variable wave length UV/VIS detector was recommended . 01 M KH,PO, (pH = 2) and methanol, and ending in 25 minutes with 60 %buffer 140 % methanol.
Stewart, J . , 5, 207 (1992). 24. H. Wang, K. Tan, S. Gong, J. Chin. Trad. , 15, 483 (1990). 25. P. Kovacs, J. Plachy, L. Szemere, and I. Racz, Acta Pharm. , 55, 85 (1985). 26. C. Smith, J. Sherma, J. , 8, 103 (1995). 27. H. Qian, W. Yamg, W. Yan, Y. He, and G. Lu, Chin. J. Hosp. , 11, 435 (1991). 28. T. Erdoss, “TLC identification of the Preservatives Salicylic Acid, Sorbic Acid, and Benzoic Acid in Wine”, Proceedings of Wines, Mesogazdasagi Klado (Agricultural Publisher), Budapest, 1986, pp. 164-167.