By Donald M. Bers PhD (auth.), Prof. Dr. G. Hasenfuss, Prof. Dr. H. Just (eds.)
Alteration of excitation-contraction coupling within the failing human center used to be deemed a fascinating topic for a discussion among uncomplicated scientists and scientific researchers in continuation of past Gargellen meetings enthusiastic about the functionality of the traditional and failing human myocardium. In 1987 uncomplicated mechanisms and scientific implications of then new insights into cardiac energetics was once by way of a complete evaluation of inotropic stimulation and myocardial energetics in 1989. the following, we undertook a second look of the foundations of inotropic stimulation and of its power healing worth, in response to new observa tions from experiments with human myocardium. In 1992 the chance as a result of myocardial phenotype switch because of model in center failure used to be released. the following, adjustments of subcellular buildings and capabilities by reason of continual middle failure, summarized as phenotype swap, can be defined as a vital attribute of the failing human myocardium. This subject used to be mentioned in larger intensity within the quantity "Cellular and Molecular changes within the Failing Human Heart", contemplating either the sarcolemma and the phosphodiesterases, in addition to excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function.
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H. MacLennan et al. 12. Jones LR, Simmerman HKB, WIlson ww, Gurd FRN, Wegener AD (1985) Purification and characterization of phospholamban from canine cardiac sarcoplasmic reticulum. J Bioi Chem 260: 'n21-'n30 13. Kim HW, Steenaart NAE, Ferguson, DG, Kranias EG (1990) Functional reconstitution ofthe cardiac sarcoplasmic reticulum ea2+ ATPase with phospholamban in phospholipid vesicles. J Bioi Chem 265: 1702-1709 14. Kimura Y, Kurzydlowski K, Thda M, MacLennan DH (1996) Phospholamban regulates the Ca2+_ ATPase through intramembrane interactions.
Cox KH. DeLeon DV. Angerer LM. Angerer RC (1984) Detection ofmRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Bioi 101 : 485-502 14. lones WK. Sanchez A. Robbins JR (1994) The murine pulmonary myocardium: developmental analysis of cardiac gene expression. Dev Dyn 200: 117-128 Phospholamban: SERCA2 regulates myocardial contractility 15. Grupp IL, Grupp G (1984) Isolated heart preparations perfused or superfused with balanced salt solutions. Methods in Pharmacol5: 111-128 16.
MacLennan DH, Brandl CJ, Korczak B, Green NM (1985) Sequence of a Ca2+ + Mg2+ dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature 316: 696-700 19. MacLennan DH, Clarke DM, Loo TW, Skerjanc I (1992a) Site-directed mutagenesis of the ea2+ ATPase of sarcoplasmic reticulum. Acta Physiol Scand 146: 141-150 20. MacLennan DH, Toyofuku T, Lytton J (1992b) Structure-function relationships in sarcoplasmic or endoplasmic reticulum type Ca2+ pumps.