Margaret F. Roberts's Alkaloids: Biochemistry, Ecology, and Medicinal Applications PDF

By Margaret F. Roberts

Not because the past due Seventies has a unmarried paintings provided the biology of this heterogenous workforce of secondary alkaloids in such intensity. Alkaloids, a distinct treatise that includes leaders within the box, provides either the ancient use of alkaloids and the newest discoveries in

  • the biochemistry of alkaloid creation in crops
  • alkaloid ecology, together with marine invertebrates, animal and plant parasites, and
  • alkaloids as antimicrobial and present medicinal use

. Highlights contain chapters at the chemical ecology of alkaloids in host-predator interactions, and at the compartmentation of alkaloids synthesis, delivery, and garage. vast cross-referencing in tabular layout makes this quantity a very good reference.

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Extra info for Alkaloids: Biochemistry, Ecology, and Medicinal Applications

Sample text

The fugu or puffer was used for murder and suicide. The toxic ingredient is the alkaloid tetrodotoxin, which inhibits nerve transmission by blocking Na t channels. Many other alkaloids and alkaloid-producing plants have been discovered to possess euphoric, psychomimetic and hallucinogenic properties (Schultes and Hofmann, 1980, 1987). , cocaine (8), reserpine (7)]. The hallucinogenic properties of plants must have puzzled early man and it is plausible that corresponding descriptions found their way into mythology.

Peganum seeds and roots are rich in harman alkaloids, such as harmin (17), harmaline (18), harmalol (49), and harman (50). As these alkaloids inhibit MAO, an enzyme essential for the metabolism of neurotransmitters, and bind to serotonin receptors, hallucinogenic and psychotropic properties could be expected. , to treat intestinal worms) spread throughout the Mediterranean area. Dioscorides had recognized it and described its different names in Syria, Egypt, and Africa. Interestingly, in Kappadocia this plant was called "moly," the same as the famous antidote mentioned in the Odyssey.

Colchicine , serpentine, ajmaline, reserpine, ergobasine, ergotamine, quinine, cinchonine, sparteine , ephedrine, lobeline , caffeine, berberine, sanguinarine, tubocurarine, strychnine, papaverine, codeine, thebaine, noscapine, yohimbine, atropine, scopolamine, morphine, vinblastine, vincristine, taxol, camptothecin) and alkaloid-containing drugs are still in use to treat various diseases (see Chapters 12 and 17). This is a clear indication that our ancestors' empirical knowledge of medicinal plants was not rubbish-as is sometimes suggested-but that it was often based on active plant constituents .

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